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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographic areas. This kind of heterogeneity, which is essential for pragmatic trials to be valid and reduce bias in results, is also necessary. However too much heterogeneity could result in problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They also provide a useful method of determining the causal relationship between the intervention and its effects. However, they should not, be used to replace explanatory studies.

The idea of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they are an addition to them. Schwartz and 라이브 카지노 Lellouch1 proposed a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a practical trial that include recruitment, design and delivery of the intervention, and the follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.