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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically focused on the practical aspects of study design, including the recruitment and 라이브 카지노 consent process, adherence, and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from various geographical areas. This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. Too much heterogeneity, however could cause issues with the trial design.

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The aim of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. They are usually requested by practitioners and policymakers to help guide their decisions. They can also be a great way to identify the cause-effect relationship between an intervention and its outcomes. They should not, however, be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a practical trial that include recruitment, design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and 프라그마틱 이미지 naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.